475221-20-6
中文名称
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40
英文名称
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
CAS
475221-20-6
分子式
C206H324N56O65
分子量
4625.11
MOL 文件
475221-20-6.mol
更新日期
2024/10/07 18:48:28
475221-20-6 结构式
基本信息
中文别名
抑制剂多肽NOGO-66 (1-40)AC-ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2
英文别名
NEP1-40NOGO-66 (1-40)
PubChem ID: 90488731
Nogo Extracellular Peptide
M.W. 4625.11 C206H324N56O65
NOGO EXTRACELLULAR PEPTIDE, 1-40
NOGO-66 (1-40) ANTAGONIST PEPTIDE
NEP1-40
NOGO EXTRACELLULAR PEPTIDE
1-40
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-P1242 | NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 NEP(1-40) | 475221-20-6 | 1 mg | 4000元 |
| 2022/09/18 | HY-P1242 | NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 NEP(1-40) | 475221-20-6 | 5 mg | 13500元 |
| 2022/09/18 | HY-P1242 | NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 NEP(1-40) | 475221-20-6 | 10 mg | 21500元 |
常见问题列表
生物活性
NEP(1-40) 是 Nogo-66 受体 (NgR) 的肽类拮抗剂，通过限制髓蛋白抑制逆转损伤引起的小胶质细胞形态分布的改变。体内研究
NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies.
| Animal Model: | 74 male Sprague-Dawley rats (328-377 g). |
| Dosage: | 89 μg/kg (97.5% PBS and 2.5% DMSO). |
| Administration: | IP, 15 min and 19 h post-injury. |
| Result: |
Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury |