476617-51-3

中文名称 476617-51-3

英文名称 Bay 41-4109 (less active enantiomer)

CAS 476617-51-3

分子式 C18H13ClF3N3O2

分子量 395.76

MOL 文件 476617-51-3.mol

476617-51-3 结构式

基本信息物理化学性质 476617-51-3价格(试剂级) 常见问题列表

基本信息

英文别名

Bay 41-4109 (less active enantiomer)
Bayer 41-4109 less active enantiomer
BAY41-4109 LESS ACTIVE ENANTIOMER
BAY-41-4109 LESS ACTIVE ENANTIOMER
BAYER 41-4109 LESS ACTIVE ENANTIOMER
methyl (4S)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4S)-

物理化学性质

储存条件-20°C储存

溶解度DMSO : ≥ 37 mg/mL (93.49 mM)

形态Solid

颜色Light yellow to yellow

476617-51-3价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2023/03/20	HY-100029B	476617-51-3 Bay 41-4109 (less active enantiomer)	476617-51-3	10mM * 1mLin DMSO	2873元
2023/03/20	HY-100029B	476617-51-3 Bay 41-4109 (less active enantiomer)	476617-51-3	5mg	3300元
2023/03/20	HY-100029B	476617-51-3 Bay 41-4109 (less active enantiomer)	476617-51-3	10mg	5000元

常见问题列表

生物活性

Bay 41-4109 less active enantiomer 是比BAY 41-4109活性低的对应体。BAY 41-4109是人乙型肝炎病毒HBV的有效抑制剂，IC50值为53 nM。

靶点

IC50: 53 nM (HBV, Bay 41-4109)

体外研究

BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro . Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC ₅₀ s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.

体内研究

BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs. BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.