478148-58-2

中文名称 PHA-543613 Dihydrochloride

英文名称 PHA-543613 Dihydrochloride

CAS 478148-58-2

分子式 C15H17N3O2

分子量 271.314

MOL 文件 478148-58-2.mol

478148-58-2 结构式

基本信息物理化学性质应用领域

基本信息

英文别名

PHA 543613E
PHA-543613 Dihydrochloride
PHA-543613 Dihydrochloride DISCONTINUED
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxaMide Dihydrochloride

物理化学性质

熔点>300?C

储存条件Refrigerator

溶解度可溶于二甲基亚砜、甲醇

形态固体

颜色Tan

应用领域

用途1

PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer鈥瞫 disease. PHA-543613 is active in both in vitro (binding, calcium flux, pat ch-clamp) and in vivo (auditory gating, novel object recognition) assays.