479-50-5
中文名称
硫坎酮
英文名称
lucanthone
CAS
479-50-5
分子式
C20H24N2OS
分子量
340.482
MOL 文件
479-50-5.mol
更新日期
2023/03/20 15:41:25
479-50-5 结构式
基本信息
中文别名
硫坎酮硫蒽酮
甲硫蒽酮
甲硫恩酮
APE-1抑制剂(LUCANTHONE)
1-((2-(二乙基氨基)乙基)氨基)-4-甲基硫杂蒽-9-酮
1-((2-(二乙氨基)乙基)氨基)-4-甲基-9H-硫杂蒽-9-酮
英文别名
Lucantonalucanthone
Lycanthone
Lucanthonum
Autophagy,inhibit,Lucanthone,Inhibitor
1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one
1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one
9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-
物理化学性质
熔点64.5°C
沸点512.4±50.0 °C(Predicted)
密度1.0915 (rough estimate)
折射率1.5950 (estimate)
储存条件-20°C储存
溶解度DMSO : 25 mg/mL (73.43 mM)
酸度系数(pKa)10.00±0.25(Predicted)
形态Solid
颜色Off-white to orange
常见问题列表
生物活性
Lucanthone是新型的自噬抑制剂，也是可用于口服的DNA嵌入剂、DNA修复酶APE1的抑制剂。靶点
APE-1
体外研究
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC 50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.