495-83-0
495-83-0 结构式
基本信息
中文别名
惕各酰托品因 英文别名
TigloidinTiglyssin
tigloidine
Tigloyltropine
Tigloyltropeine
Tiglylpseudotropine
3α-Tigloyloxytropane
Tigloyl pseudotropine
2-Methylcrotonic acid (1R,5S)-tropan-3β-yl ester
2-Butenoic acid, 2-methyl-, (3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (2E)-
物理化学性质
沸点290.2±33.0 °C(Predicted)
密度1.06±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系数(pKa)10.03±0.40(Predicted)
形态Oil
颜色Light yellow to yellow
常见问题列表
生物活性
Tigloidin 是 atropine 的类似物，具有抗胆碱能的活性。体内研究
Tigloidine hydrobromide (20-60 mg/kg, i.p.) fails to protect the mice against the lethal effect of physostigmine, but at 100 mg/kg and above, it protects 80% of the animals against the lethal effect. Tigloidine markedly prevents tremor and salivation produced by tremorine at 80-100 mg/kg, but fails to prevent these effects in doses up to 40 mg/kg. Tigloidine (up to 100 mg/kg, i.p) does not significantly affects reserpine and tetrabenazine induced sedation and ptosis in mice. Tigloidine (25-50 mg/kg, i.p.) also fails to cause any behavioral changes in the cats.