500565-15-1
中文名称
4-((6-氯-2-甲氧基吖啶-9-基)氨基)-2-((4-甲基哌嗪-1-基)甲基)苯酚
英文名称
4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol
CAS
500565-15-1
分子式
C26H27ClN4O2
分子量
462.97
MOL 文件
500565-15-1.mol
500565-15-1 结构式
基本信息
中文别名
化合物HM034-((6-氯-2-甲氧基吖啶-9-基)氨基)-2-((4-甲基哌嗪-1-基)甲基)苯酚
英文别名
HM03HM03 (NSC130813)
Phenol, 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-
shock,HM 03,inhibit,heat,tumor,cancer,cell,HM03,protein,Heat shock proteins,HSP,Inhibitor,HCT116,HM-03
物理化学性质
沸点603.7±55.0 °C(Predicted)
密度1.327±0.06 g/cm3(Predicted)
酸度系数(pKa)10.20±0.50(Predicted)
形态Solid
颜色Pink to red
常见问题列表
生物活性
HM03 是一种有效的选择性的热休克 70 kDa 蛋白 5, HSPA5 (也称为 Bip，Grp78) 抑制剂，具有抗肿瘤活性。靶点
|
HSPA5
|
体外研究
HM03 (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells.
HM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins.
HM03 exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays.
Cell Viability Assay
| Cell Line: | HCT116 cells |
| Concentration: | 0.1, 1, 10, 25, 50 μM |
| Incubation Time: | 72 hours |
| Result: | Exhibited prominent inhibition effect (18% survival at 25 µM). |