50932-19-9
中文名称
梓醇 6-咖啡酸酯
英文名称
[(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside
CAS
50932-19-9
分子式
C24H28O13
分子量
524.48
MOL 文件
50932-19-9.mol
50932-19-9 结构式
基本信息
中文别名
梓醇 6-咖啡酸酯 英文别名
VermisideVerminoside
Caffeoyl catalpol
Catalpol 6-caffeate
[(1aS)-6α-[[(E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1a,1bα,2,5aα,6,6aβ-hexahydro-1a-hydroxymethyloxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside
β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-6-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl
所属类别
天然产物：环烯醚萜衍生物常见问题列表
生物活性
Verminoside 是从 Kigelia africana 分离出的一种环烯醚萜，具有抗炎和显着的抗氧化活性，其自由基清除活性为 2.5 μg/mL。Verminoside 对人淋巴细胞的遗传毒性与 PARP-1 和 p53 蛋白水平升高有关。靶点
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PARP-1
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体外研究
Verminoside (Compound 1; 0.01-1 mM; 25 hours; J774.A1 macrophages) treatment shows significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages.
Western Blot Analysis
| Cell Line: | J774.A1 macrophages |
| Concentration: | 0.01 mM, 0.1 mM or 1 mM |
| Incubation Time: | 25 hours |
| Result: | Showed significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages. |