511514-03-7

中文名称 4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine

英文名称 4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine

CAS 511514-03-7

分子式 C21H21N5

分子量 343.42

MOL 文件 511514-03-7.mol

511514-03-7 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T13983

英文别名

185582
0990CL
4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl-
(4-phenyl-quinazolin-2-yl)-(4,6,6-trimethyl-1,6-dihydro-pyrimidin-2-yl)-amine

物理化学性质

沸点519.5±58.0 °C(Predicted)

密度1.21±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO : 50 mg/mL (145.59 mM; Need ultrasonic)

酸度系数(pKa)7.10±0.60(Predicted)

形态Solid

颜色Light yellow to yellow

常见问题列表

生物活性

0990CL 是能够与 Gαi 直接相互作用的，异源三聚体 Gαi subunit 特异性抑制剂。0990CL 能够阻断 α2AR 介导的 cAMP 调节。

靶点

IC50: Gαi subunit

体外研究

0990CL (100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP.0990CL (30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively.