5122-36-1
中文名称
4,6-二氨基-5-甲酰胺基嘧啶
英文名称
4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE
CAS
5122-36-1
分子式
C5H7N5O
分子量
153.14
MOL 文件
5122-36-1.mol
更新日期
2024/11/11 11:01:29
5122-36-1 结构式
基本信息
中文别名
二氨基-15N2,98%)4,6-二氨基-5-甲酰胺基嘧啶
法比腺嘌呤(甲酰-13C,98%
4,6-二氨基-5-甲酰基氨基嘧啶
4,6-二氨基-5-甲酰胺基嘧啶盐酸盐
4,6-二氨基-5-甲酰基氨基嘧啶盐酸盐
英文别名
FAPy-adenineDIAMINO-15N2)
DIAMINO-15N2, 98%)
FAPYADENINE(FORMYL-13C
4,6-diamino-5-n-formamidopyrimidine
4,6-DIAMONO-5-(FORMYLAMINO)PYRIMIDNE
4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE
N-(4,6-Diaminopyrimidin-5-yl)formamide
Formamide, N-(4,6-diamino-5-pyrimidinyl)-
4,6-Diamino-5-(Formylamino)-Pyrimidine HCl
物理化学性质
熔点224-226 °C
沸点536.1±50.0 °C(Predicted)
密度1.575±0.06 g/cm3(Predicted)
储存条件−20°C
酸度系数(pKa)12.35±0.70(Predicted)
形态Solid
颜色Off-white to light yellow
常见问题列表
生物活性
FAPy-adenine 是一种氧化的 DNA 碱基。FAPy-adenine 在阿尔茨海默病脑中呈上升趋势。氧化核苷是肿瘤、衰老和神经退行性疾病的生化标志物。靶点
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Human Endogenous Metabolite
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体外研究
In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine.
体内研究
The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease.