514-07-8
中文名称
蒲公英萜酮
英文名称
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
CAS
514-07-8
分子式
C30H48O
分子量
424.7
MOL 文件
514-07-8.mol
更新日期
2023/11/22 17:16:08
514-07-8 结构式
基本信息
中文别名
蒲公英赛酮蒲公英萜酮
蒲公英萜酮, 来源于南沙参
英文别名
TarxeroneTaraxeron
Taraxera-14-ene-3-one
D-Friedoolean-14-en-3-one
27-Norolean-14-en-3-one,13-methyl-, (13a)-
27-Norolean-14-en-3-one, 13-methyl-, (13α)-
Taraxerone, 98%, from Adenophora tetraphylla(Thunb.)Fisch
(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one
所属类别
天然产物：萜类物理化学性质
外观性状白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于淡竹叶、蒲公英。
熔点241-243 °C
沸点488.3±44.0 °C(Predicted)
密度1.01±0.1 g/cm3(Predicted)
储存条件-20°C储存
形态Solid
颜色White to off-white
LogP10.480 (est)
常见问题列表
生物活性
Taraxerone 是从景天中分离出来的。Taraxerone 增强乙醇脱氢酶 (ADH) 和乙醛脱氢酶 (ALDH) 活性，EC50 值分别为 512.42 μM 和 500.16 μM。靶点
EC50: 512.42 μM (ADH); 500.16 μM (ALDH)
体内研究
Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure. Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration.