514-67-0

中文名称红斑红素

英文名称 RUBROPUNCTATIN

CAS 514-67-0

分子式 C21H22O5

分子量 354.4

MOL 文件 514-67-0.mol

更新日期 2024/07/03 22:51:59

514-67-0 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

红斑红素
514-67-0

英文别名

RUBROPUNCTATIN
Rubropuncatatin
(9aR)-3-hexanoyl-9a-methyl-6-[(E)-prop-1-enyl]furo[3,2-g]isochromene-2,9-dione
(R-(E))-9A-Methyl-3-(1-oxohexyl)-6-(1-propenyl)-2H-furo(3,2-G)(2)benzopyran-2,9(9ah)-dione
(R)-9a-Methyl-3-(1-oxohexyl)-6-[(E)-1-propenyl]-2H-furo[3,2-g][2]benzopyran-2,9(9aH)-dione
2H-Furo(3,2-G)(2)benzopyran-2,9(9ah)-dione, 9A-methyl-3-(1-oxohexyl)-6-(1-propenyl)-, (R-(E))-
2H-Furo[3,2-g][2]benzopyran-2,9(9aH)-dione, 9a-methyl-3-(1-oxohexyl)-6-(1E)-1-propen-1-yl-, (9aR)-

所属类别

生物化工：抑制剂

物理化学性质

熔点156.5-157.0 °C (decomp)(Solv: ethyl ether (60-29-7))

沸点638.8±55.0 °C(Predicted)

密度1.23±0.1 g/cm3(Predicted)

形态Solid

颜色Yellow to orange

常见问题列表

生物活性

Rubropunctatin 是一种从红曲霉发酵米(红霉米)提取物中分离出来的橙色的氮杂酮类色素。 Rubropunctatin 具有抗炎，免疫抑制和抗氧化作用，还具有抗肿瘤活性。

体外研究

Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1.
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells.
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity.

Cell Viability Assay

Cell Line:	BGC-823 and GES-1cells
Concentration:	1.5, 3, 6, 12, 15, 18, 30 μM
Incubation Time:	24 hours
Result:	Decreased the viability of BGC-823 cells with an IC ₅₀ of 12.57 μM for 24 h. Did not show obvious cytotoxic effects on the normal cells.

Cell Cycle Analysis

Cell Line:	BGC-823 cells
Concentration:	0, 5, 10, 30 μM
Incubation Time:	0, 6, 12, 24 hours
Result:	Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.

体内研究

Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice.
Rubropunctamine inhibits 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID ₅₀ of 0.11 mg/ear.

Animal Model:	Male nude mice (5 weeks) are inoculated with BGC-823 cells
Dosage:	8, 32 mg/kg
Administration:	I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:	Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg). Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg). No significant difference was observed on the body weight.