52029-86-4
中文名称
STO-609
英文名称
7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
CAS
52029-86-4
分子式
C19H10N2O3
分子量
314.29
MOL 文件
52029-86-4.mol
更新日期
2024/12/23 17:39:03
52029-86-4 结构式
基本信息
中文别名
化合物STO609 英文别名
STO-609STO-609, >98%
STO609
STO 609
STO-609 ACETATE
STO-609 free base
STO-609 ACETIC ACID
STO-609 - CAS 52029-86-4 - Calbiochem
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid
7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-
7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点>300 °C
沸点716.9±62.0 °C(Predicted)
密度1.54±0.1 g/cm3(Predicted)
储存条件Sealed in dry,2-8°C
溶解度DMSO: 15 mg/mL at ≥60 °C
酸度系数(pKa)2.65±0.20(Predicted)
形态solid
颜色Light yellow to yellow
应用领域
用途1
一种特异性的CaM-KK的抑制剂，抑制CaM-KKα和CaM-KKβ，Ki值分别为80ng/ml和15ng/ml，并抑制其自身磷酸化活性。STO-609 is a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. STO-609 inhibits the activities of recombinant CaM-KK alpha and CaM-KK beta isoforms, with K(i) values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC(50) value of the compound against CaM-KII is approximately 10 microg/ml. STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo as well as in vitro.STO-609价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-19805 | STO-609 STO-609 | 52029-86-4 | 1mg | 400元 |
| 2024/11/08 | HY-19805 | STO-609 STO-609 | 52029-86-4 | 5mg | 800元 |
| 2024/11/08 | HY-19805 | STO-609 STO-609 | 52029-86-4 | 10mg | 1280元 |
常见问题列表
生物活性
STO-609 是特异性的CaM-KK的抑制剂，抑制CaM-KKα和CaM-KKβ的活性，Ki值分别为80 ng/ml和15 ng/ml，并抑制其自身磷酸化活性。STO-609 可抑制 AMPKK 活性并抑制自噬。靶点
| Target | Value |
|
AMPK
() | |
|
CaM-KKβ
(Cell-free assay) | 47 nM(Ki) |
|
CaM-KKα
(Cell-free assay) | 0.25 μM(Ki) |
体外研究
STO-609抑制重组CaM-KKα和CaM-KKβ的活性，Ki值分别为80 ng/ml和15 ng/ml，STO-609还抑制它们的自身磷酸化活性。STO-609对CaM-KK具有高度选择性，对其下游 CaM激酶(CaM-KI and -IV)没有显著作用。在转染的Hela细胞中，STO-609以剂量依赖方式抑制Ca。
体内研究
对成年小鼠体内给药，STO-609会引起造骨细胞的增多、破骨细胞的减少，对卵巢切除术引发的骨质疏松症具有保护作用。脑室注射STO-609不影响对神经低血糖症的负调节反应、对低血糖引起的AMPK激活也没有影响。