521310-51-0
中文名称
化合物 T24437
英文名称
BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
CAS
521310-51-0
分子式
C33H36N2O3
分子量
508.65
MOL 文件
521310-51-0.mol
更新日期
2024/07/23 11:55:39
521310-51-0 结构式
基本信息
中文别名
化合物MCP110化合物 T24437
英文别名
MCP110N-(4-(benzyloxy)-3-Methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanaMide
astrocytomas,Inhibitor,Raf kinases,colorectal,cancer,MCP110,inhibit,Raf-1,Raf,Ras
BenzenepentanaMide, N-[[3-Methoxy-4-(phenylMethoxy)phenyl]Methyl]-N-[2-(2-pyridinyl)ethyl]-
常见问题列表
生物活性
MCP110 是一种 Ras/Raf-1 相互作用的抑制剂。MCP110 可破坏激活的Ras与Raf的相互作用，具有治疗人类肿瘤的潜力。靶点
| Target | Value |
|
Raf-1
() | |
|
Ras-Raf interaction
() |
体外研究
MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 μM) .
MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells.
MCP110 (20 μM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells.