52811-37-7
中文名称
2,5-二羟基-4-甲氧基二苯甲酮
英文名称
Cearoin
CAS
52811-37-7
分子式
C14H12O4
分子量
244.24
MOL 文件
52811-37-7.mol
更新日期
2023/03/20 15:41:17
52811-37-7 结构式
基本信息
中文别名
2,5-二羟基-4-甲氧基二苯甲酮 英文别名
Cearoin(2,5-dihydroxy-4-methoxyphenyl)phenylmethanone
Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone
Methanone, (2,5-dihydroxy-4-methoxyphenyl)phenyl-
物理化学性质
熔点188 °C(Solv: ethanol (64-17-5))
沸点443.8±45.0 °C(Predicted)
密度1.296±0.06 g/cm3(Predicted)
储存条件4°C, protect from light
酸度系数(pKa)8.25±0.48(Predicted)
形态Solid
颜色Light yellow to green yellow
2,5-二羟基-4-甲氧基二苯甲酮价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-N8418 | 2,5-二羟基-4-甲氧基二苯甲酮 Cearoin | 52811-37-7 | 1mg | 2500元 |
常见问题列表
生物活性
Cearoin 可从Dalbergia odorifera中分离，通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。靶点
|
ERK
|
ROS
|
Autophagy
|
Apoptosis
|
体外研究
Cearoin (10-80 μM) induces cell death in a dose-dependent manner.
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells.
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process.
Cell Viability Assay
| Cell Line: | Human neuroblastoma SH-SY5Y cells |
| Concentration: | 0, 1, 5, 10, 20, 40, or 80 μM |
| Incubation Time: | 6 or 12 hours |
| Result: | Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. |
Western Blot Analysis
| Cell Line: | Human neuroblastoma SH-SY5Y cells |
| Concentration: | 0, 5, 10, 20, 40, or 80 μM |
| Incubation Time: | 12 hours |
| Result: |
Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner. |