53342-16-8
53342-16-8 结构式
基本信息
中文别名
环[2-甲基丙氨酰-L-苯丙氨酰-D-脯氨酰-(ALPHAS,2S)-ALPHA-氨基-H-氧代-2-环氧乙烷辛酰 英文别名
SL-3440CHLAMYDOCIN
Antibiotic SL-3440
2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-]
Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl]
Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl]
物理化学性质
沸点861.8±65.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: soluble; Ethanol: soluble; Methanol: soluble
酸度系数(pKa)13.36±0.70(Predicted)
形态固体
常见问题列表
生物活性
Chlamydocin，一种真菌代谢产物，是一种高效的 HDAC 抑制剂，IC50 为 1.3 nM。Chlamydocin 具有很强的抗增殖和抗癌活性。Chlamydocin 通过激活 caspase-3 诱导细胞凋亡。靶点
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HDAC 1.3 nM (IC 50 ) |
体外研究
Chlamydocin is originally isolated from the fungus Diheterospora chlamydosporia . Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle.