54301-15-4
![54301-15-4 结构式](/CAS/GIF/54301-15-4.gif)
基本信息
安沙克林
盐酸安吖啶
安吖啶盐酸盐
盐酸胺苯吖啶
盐酸胺苯吖啶, ≥98% (HPLC)
N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺
N-[4-(9-吖啶氨基)-3-甲氧苯基]甲基磺酰胺盐酸盐
4-(9-吖啶基氨基)-N-(甲磺酰基)-间甲氧基苯胺盐酸盐
盐酸胺苯吖啶,安吖啶,胺苯吖啶,N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺
nci-c03190
M-AMSA, HCL
M-Amsacrine
META-AMSACRINE
AMSA hydrochloride
M-AMSA HYDROCHLORIDE
AMSACRINE HYDROCHLORIDE
acridinyl anisidide hydrochloride
AMine hydrochloride benzene acridine
物理化学性质
安全数据
常见问题列表
Target | Value |
Topo II
() |
Amsacrine (mAMSA) blocks HERG currents in HEK 293 cells and Xenopus oocytes in a concentration-dependent manner, with IC 50 values of 209.4 nM and 2.0 μM, respectively. Amsacrine (mAMSA) causes a negative shift in the voltage dependence of both activation (−7.6 mV) and inactivation (−7.6 mV). HERG current block by Amsacrine (mAMSA) is not frequency dependent. In vitro studies of normal human lymphocytes with various concentrations of Amsacrine (mAMSA), show both increased levels of chromosomal aberrations, ranging from 8% to 100%, and increase SCEs, ranging from 1.5 times the normal at the lowest concentration studied (0.005 μg/mL) to 12 times the normal (0.25 μg/mL). Amsacrine (mAMSA)-induced apoptosis of U937 cells is characterized by caspase-9 and caspase-3 activation, increased intracellular Ca 2+ concentration, mitochondrial depolarization, and MCL1 down-regulation. Amsacrine induces MCL1 down-regulation by decreasing its stability. Further, amsacrine-treated U937 cells show AKT degradation and Ca 2+ -mediated ERK inactivation.
In animals treated with different doses of amsacrine (0.5-12 mg/kg), the frequencies of micronucleated polychromatic erythrocytes increase significantly after treatment with 9 and 12 mg/kg. Furthermore, the present study demonstrates for the first time that Amsacrine (mAMSA) has high incidences of clastogenicity and low incidences of aneugenicity whereas nocodazole has high incidences of aneugenicity and low incidences of clastogenicity during mitotic phases in vivo.