544450-68-2

中文名称 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester

英文名称 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester

CAS 544450-68-2

分子式 C16H16ClNO3S

分子量 337.82

MOL 文件 544450-68-2.mol

更新日期 2023/03/20 15:41:27

544450-68-2 结构式

基本信息物理化学性质 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester价格(试剂级) 常见问题列表

基本信息

中文别名

2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯

英文别名

COR659
Methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate
3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester

物理化学性质

储存条件4°C, away from moisture and light

溶解度DMSO: 33.33 mg/mL (98.66 mM)

形态Solid

颜色Off-white to light yellow

3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-137204	2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯 COR659	544450-68-2	5mg	2400元
2024/04/30	HY-137204	2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯 COR659	544450-68-2	10mM * 1mLin DMSO	2640元
2024/04/30	HY-137204	2-(4-氯苯甲酰胺基)-4-乙基-5-甲基噻吩-3-羧酸甲酯 COR659	544450-68-2	25mg	5900元

常见问题列表

生物活性

COR659 是有效的 GABAB 的阳性变构调节剂 (PAM)。COR659 可缓解大鼠对酒精和巧克力的药物成瘾。

体外研究

COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA _B receptor and an action at the cannabinoid CB1 receptor.

体内研究

COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats.
COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.

Animal Model:	Male sP and Wistar rats.
Dosage:	0, 2.5, 5 and 10 mg/kg.
Administration:	Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.).
Result:	The magnitude of the reducing effect of the compound on number oflever-responses for alcohol averaged approximately 30, 55, and 70%, in comparison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively. The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.