548-61-8
基本信息
-三氨基三苯甲烷
參(對胺苯)甲烷
三(4-苯胺基)甲烷
三(4-氨基苯基)甲烷
4,4’,4"-三氨基三苯甲烷
4,4`,4```-三氨基三苯甲烷
-三氨基三苯甲烷/三(4-氨基苯基)甲烷
p-leucaniline
JACS-548-61-8
p-Leucoaniline
paraleucaniline
leucoparafuchsin
Paraleucoaniline
leucoparafuchsine
Leucopararosaniline
tris-4-aminofenylmethan
物理化学性质
制备方法
用氢氧化钠溶液、硫黄配制多硫化钠,用多硫化钠作还原剂,在乙醇介质中将对硝基甲苯氧化还原,生成对氨基苯甲醛。后者在盐酸存在下与苯胺缩合,生成三(4-氨基苯基)甲烷盐酸盐,经烧碱中和、蒸出苯胺,再经盐酸酸化、活性炭脱色、液碱中和、干燥、粉碎,得成品。合成反应式如下
常见问题列表
4,4’,4"-三氨基三苯甲烷是丙型肝炎病毒解旋酶的抑制剂。4,4’,4"-三氨基三苯甲烷具有致癌活性,增加了动物直肠内皮系统肿瘤的发生率。
HCV helicase
Tris(4-aminophenyl)methane (Compound 8) shows weak HCV helicase inhibition (30% inhibition at 100 μM). To preserve RNA in a biological sample for analysis, the sample is incubated with an RNA preservative capable of precipitating RNA in an aqueous solution, such as a triphenylmethane dye (e.g., methyl green, crystal violet, pararosaniline, or Tris(4-aminophenyl)methane), cresyl violet, or cobalt ions. RNA preservation may be used in an immunostaining assay and other histochemical methods.