5534-18-9
中文名称
9Α-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17-丙酸酯
CAS
5534-18-9
分子式
C25H33ClO6
分子量
464.979
MOL 文件
5534-18-9.mol
更新日期
2024/07/11 14:34:27
5534-18-9 结构式
基本信息
中文别名
9Α-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17-丙酸酯 英文别名
Beclomethasone EP Impurity Hbeclomethasone 17-monopropionate
9-Chloro-11,21-dihydroxy-16-methyl-17-propionyloxypregna-1,4-diene-3,20-dione
9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propanoate
9-Chloro-11β,21-dihydroxy-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate
9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
9-Chloro-11β-hydroxy-16β-methyl-17α-(propionyloxy)-21-hydroxypregna-1,4-diene-3,20-dione
(11,16)-9-Chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
常见问题列表
生物活性
Beclomethasone 17-propionate (Beclomethasone-17-monopropionate) 是 Beclomethasone dipropionate (HY-13571) 的活性代谢产物，是糖皮质激素受体 (GR) 激动剂。Beclomethasone 17-propionate 对 GR 的亲和力比 Beclomethasone dipropionate 高。Beclomethasone 17-propionate 有效抑制慢性阻塞性肺疾病 (COPD) 肺巨噬细胞中细胞因子的产生。体外研究
Metabolism of Beclomethasone dipropionate to 17-BMP is an important activation step. Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα and IL-6. The EC 50 values of Beclomethasone 17-propionate for IL-6, TNFα and CXCL8 were 0.05 nM, 0.01 nM and 0.1 nM, respectively. Beclomethasone 17-propionate evokes upregulation of the GR dependent genes FKBP51 and GILZ.