56776-32-0

中文名称盐酸艾替伏辛

英文名称 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride

CAS 56776-32-0

分子式 C17H18Cl2N2O

分子量 337.244

MOL 文件 56776-32-0.mol

更新日期 2023/03/20 15:41:25

56776-32-0 结构式

基本信息物理化学性质安全数据图谱信息盐酸艾替伏辛价格(试剂级) 常见问题列表

基本信息

中文别名

盐酸艾替伏辛
盐酸依替福辛
艾替伏辛盐酸盐

英文别名

StresaM
HOE-36801 hydrochloride
Etifoxine·hydrochloride
NSC 163501
ANTIBIOTIC AT-125
U 42126
2-EthylaMino-6-chloro-4-Methyl-4-phenyl-4H-3,1-benzoxazine Hydrochloride
6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride
6-Chloro-N-ethyl-4-Methyl-4-phenyl-4H-3,1-benzoxazin-2-aMine Hydrochloride
6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride
6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride

物理化学性质

熔点ND

储存条件-20°C

溶解度二甲基亚砜：≥5mg/mL

形态粉末

颜色白色至米色

稳定性吸湿性

安全数据

危险性符号(GHS)

GHS07,GHS05

警示词危险

危险性描述H302-H318

防范说明P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310

危险品标志Xn

危险类别码22

WGK Germany3

图谱信息

盐酸艾替伏辛(56776-32-0)核磁图(¹HNMR)

盐酸艾替伏辛价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/08/19	HY-16579	盐酸艾替伏辛 Etifoxine hydrochloride	56776-32-0	5mg	700元
2024/08/19	HY-16579	盐酸艾替伏辛 Etifoxine hydrochloride	56776-32-0	10mM * 1mLin DMSO	770元
2024/08/19	HY-16579	盐酸艾替伏辛 Etifoxine hydrochloride	56776-32-0	10mg	1000元

常见问题列表

生物活性

Etifoxine hydrochloride是一个非苯二氮卓类的、具有 GABA 能的化合物，是 GABAA 受体亚基 α1β2γ2 和 α1β3γ2 的阳性变构调节剂。Etifoxine hydrochloride 在啮齿类动物中显示出抗焦虑和抗惊厥活性。

体外研究

Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX.

体内研究

Etifoxine competitively inhibits [ ³⁵ S]TBPS binding with micromolar potency in rat brain.
Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice.

Animal Model:	Six-week old BALB/cByJ and C57BL/6J mice (20-25 g).
Dosage:	3.125-50 mg/kg.
Administration:	Intraperitoneal inhection.
Result:	Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice. BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min.