568588-77-2
中文名称
Hemopressin (rat)
英文名称
Hemopressin (rat)
CAS
568588-77-2
分子式
C53H77N13O12
分子量
1088.26
MOL 文件
568588-77-2.mol
568588-77-2 结构式
基本信息
中文别名
血红蛋白 Α1 链HEMOPRESSIN(RAT) 英文别名
Hemopressin (rat)Hemopressin from rat
Hemopressin from rat brain
HeMopressin trifluoroacetate salt
Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His trifluoroacetate salt
L-Histidine, L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-phenylalanyl-L-leucyl-L-seryl-
L-Prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-phenylalanyl-L-leucyl-L-seryl-L-histidine trifluoroacetate salt
常见问题列表
生物活性
Hemopressin(rat) 是一种源自血红蛋白 α1 链的九肽，最初是从大鼠脑匀浆中分离出来的。Hemopressin(rat) 是口服有效的，选择性的 CB1 大麻素受体的反向激动剂。Hemopressin(rat) 在炎性疼痛模型中发挥抗伤害感受作用。体内研究
Hemopressin(rat) causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE).
Oral administration of Hemopressin(rat) inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin(rat) treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats.