577784-91-9

中文名称 RNA Polymerase III Inhibitor

CAS 577784-91-9

分子式 C19H15Cl2N3O2S2

分子量 452.38

MOL 文件 577784-91-9.mol

577784-91-9 结构式

基本信息物理化学性质图谱信息常见问题列表

基本信息

英文别名

RNA Polymerase III Inhibitor
RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide
Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-

物理化学性质

储存条件= -70C

形态类白色固体

图谱信息

RNA Polymerase III Inhibitor(577784-91-9)核磁图(¹HNMR)

常见问题列表

生物活性

ML-60218 是一种广谱 RNA pol III 抑制剂，对酿酒酵母和人类 RNA pol III 的 IC50 分别为 32 和 27 μM。ML-60218 破坏已经组装好的病毒体，并且在不需要重新转录细胞 RNA 的情况下阻碍新病毒体的形成。

体外研究

Combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis. ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest.
In in vitro transcription assays with purified double-layered particles (DLPs), ML-60218 shows dose-dependent inhibitory activity, indicating the viral nature of its target. ML-60218 is found to interfere with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation.