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5786-54-9

中文名称 Hispidol
英文名称 6,4''-DIHYDROXYAURONE
CAS 5786-54-9
分子式 C15H10O4
分子量 254.24
MOL 文件 5786-54-9.mol
更新日期 2024/07/03 16:58:40
5786-54-9 结构式 5786-54-9 结构式

基本信息

中文别名
化合物HISPIDOL
英文别名
NSC356828
(Z)-Hispidol
Hispidol, >98%
3(2H)-Benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2Z)-

物理化学性质

熔点286-288 °C
沸点523.8±50.0 °C(Predicted)
密度1.489±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml
酸度系数(pKa)7.59±0.20(Predicted)
形态固体
颜色Light yellow to yellow
Hispidol价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2023/01/06S0248Hispidol
Hispidol
5786-54-95mg2841.93元
2023/01/06S0248Hispidol
Hispidol
5786-54-925mg8591.31元

常见问题列表

生物活性
Hispidol ((Z)-Hispidol) 具有研究炎症性肠病的潜力,能够抑制 TNF-α 诱导的单核细胞对结肠上皮细胞的粘附,IC50 值为 0.50 µM。
体外研究

Hispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression.

体内研究

The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner.

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