57935-66-7
中文名称
尼麦角林杂质Ⅵ(EP杂质E)
英文名称
Ergoline-8-methanol, 10-hydroxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
CAS
57935-66-7
分子式
C23H24BrN3O3
分子量
470.37
MOL 文件
57935-66-7.mol
更新日期
2024/08/05 10:25:47
57935-66-7 结构式
基本信息
中文别名
尼麦角林杂质07尼麦角林杂质Ⅵ(EP杂质E)
英文别名
NicergolineImpurity210α-Hydroxy Nicergoline
Ergoline-8-methanol Indolo[4,3-fg]quinoline Derivative
Ergoline-8-methanol, 10-hydroxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
所属类别
分析化学：药典标准品和杂质标准品应用领域
用途一
10α-Hydroxy Nicergoline is an impurity of Nicergoline (N394550) which is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.