58001-19-7
中文名称
尼麦角林杂质Ⅶ(EP杂质F)
英文名称
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8α)-
CAS
58001-19-7
分子式
C24H26BrN3O3
分子量
484.39
MOL 文件
58001-19-7.mol
更新日期
2024/07/08 11:49:14
58001-19-7 结构式
基本信息
中文别名
尼麦角林杂质Ⅶ(EP杂质F) 英文别名
IsonicergolineErgoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8α)-
((6aR,9S,10aS)-10a-methoxy-4,7-dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl 5-bromonicotinate
所属类别
分析化学：对照品应用领域
用途一
8-epi Nicergoline is an impurity of Nicergoline (N394550) which is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.