582323-16-8
中文名称
ICA 069673
英文名称
ICA 069673
CAS
582323-16-8
分子式
C11H6ClF2N3O
分子量
269.63
MOL 文件
582323-16-8.mol
更新日期
2023/03/20 15:41:27
582323-16-8 结构式
基本信息
中文别名
化合物ICA069673 英文别名
ICA 069673ICA069673
ICA-069673
ICA-069673 >=98% (HPLC)
N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
物理化学性质
沸点358.9±37.0 °C(Predicted)
密度1.539±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Room Temperature
溶解度DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
酸度系数(pKa)9.47±0.70(Predicted)
形态粉末
颜色White to off-white
ICA 069673价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-101396 | ICA 069673 ICA-069673 | 582323-16-8 | 5mg | 770元 |
| 2024/04/30 | S0144 | ICA 069673 ICA 069673 | 582323-16-8 | 5mg | 779.46元 |
| 2024/04/30 | HY-101396 | ICA 069673 ICA-069673 | 582323-16-8 | 10mM * 1mLin DMSO | 847元 |
常见问题列表
生物活性
ICA 069673 (compound 51) 是一种口服活性、有效的 KCNQ2/Q3 potassium channel 的选择性激活剂，其对KCNQ2/Q3和KCNQ3/Q5的EC50值分别为0.69 μM和14.3 μM。靶点
| Target | Value |
|
KCNQ2/Q3
(Cell-free assay) | 0.69 μM(EC50) |
|
KCNQ3/Q5
(Cell-free assay) | 14.3 μM(EC50) |
体外研究
ICA-069673 is found to be 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5 and has no measurable activity against a panel of cardiac ion channels (IC 50 values > 30 μM for hERG, Nav1.5, L type channels, and KCNQ1) as well as no activity on GABA(A) gated channels at 10 μM. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, an 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. Based on ICA73 sensitivity of chimeric constructs of the transmembrane segments of KCNQ2 and KCNQ3, this drug appears to interact with the KCNQ2 voltage sensor (S1-S4).