5853-29-2
中文名称
盐酸吐根酚碱
英文名称
cephaeline hydrochloride
CAS
5853-29-2
分子式
C28H39ClN2O4
分子量
503.08
MOL 文件
5853-29-2.mol
更新日期
2024/07/19 11:56:54
5853-29-2 结构式
基本信息
中文别名
吐根酚碱盐酸盐 EP标准品 英文别名
NSC 32944Cephaeline DiHCl
Cephaeline HCl salt
cephaelin hydrochloride
Cephaeline dihydrochloride
Cephaeline dihydrochloroide
Cephaeline hydrochloride CRS
(-)-CEPHAELINE DIHYDROCHLORIDE
(1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol hydrochloride
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
外观性状类白至黄色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于吐根，安哥拉八角枫。
储存条件4°C, protect from light
溶解度溶于二甲基亚砜
形态neat
颜色White to off-white
盐酸吐根酚碱价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-N2260 | 盐酸吐根酚碱 Cephaeline dihydrochloride | 5853-29-2 | 5mg | 1200元 |
| 2024/04/30 | HY-N2260 | 盐酸吐根酚碱 Cephaeline dihydrochloride | 5853-29-2 | 25 mg | 3600元 |
| 2024/04/30 | HY-N2260 | 盐酸吐根酚碱 Cephaeline dihydrochloride | 5853-29-2 | 50 mg | 5800元 |
常见问题列表
生物活性
Cephaeline dihydrochloride 是选择性的 CYP2D6 抑制剂，IC50 为 121 μM。靶点
IC50: 121 μM (CYP2D6)
Ki: 54 μM (CYP2D6)
体外研究
CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively.