58872-39-2
中文名称
H-VAL-PRO-PRO-OH
英文名称
H-VAL-PRO-PRO-OH
CAS
58872-39-2
分子式
C15H25N3O4
分子量
311.38
MOL 文件
58872-39-2.mol
更新日期
2024/07/07 16:57:51
58872-39-2 结构式
基本信息
中文别名
(2S)-1-[(2S)-1-[(2S)-2-AMINO-3-METHYLBUTANOYL]PYRROLIDINE-2-CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID 英文别名
VPP TripeptideH-VAL-PRO-PRO-OH
L-Proline, L-valyl-L-prolyl-
(S)-1-((S)-1-((S)-2-AMino-3-Methylbutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid
物理化学性质
沸点566.4±50.0 °C(Predicted)
密度1.274±0.06 g/cm3(Predicted)
储存条件Sealed in dry,2-8°C
溶解度溶于二甲基亚砜
酸度系数(pKa)3.42±0.20(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
H-Val-Pro-Pro-OH，是牛奶来源的脯氨酸肽衍生物，是血管紧张素 I 转化酶 (ACE) 的抑制剂，其IC50 为 9 μM。靶点
IC50: 9 μM (ACE).
体外研究
H-Val-Pro-Pro-OH, a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC 50 of 9 μM. H-Val-Pro-Pro-OH could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes.