59450-89-4
59450-89-4 结构式
基本信息
中文别名
卡西霉素A23187 半钙盐
钙离子载体 A23187 半钙盐
英文别名
A23187 HEMICALCIUM SALTCALCIMYCIN A23187 HEMICALCIUM SALT
Antibiotic A-23187 hemicalcium salt
calcium ionophore A23187 hemicalcium
CALCIUM IONOPHORE A23187 HEMICALCIUM SALT
Calcium Ionophore A23187 hemicalcium salt powder
CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA
A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt
5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
常见问题列表
生物活性
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) 是一种抗生素和独特的二价阳离子离子载体 (divalent cation ionophore)，如钙离子和镁离子。Calcimycin hemicalcium salt 通过增加细胞内钙浓度诱导 Ca2+ 依赖性细胞死亡。Calcimycin hemicalcium salt 抑制革兰氏阳性细菌和一些真菌的生长，还抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化 (OXPHOS)，诱导细胞凋亡 (apoptosis)。体外研究
Calcimycin hemicalcium salt (A-23187 calcium) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.
体内研究
Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage.
| Animal Model: | Mice (ICR, 25-30 g) |
| Dosage: | 2.5 or 7.5 nM |
| Administration: | Intrapleurally |
| Result: | Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values. |