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60607-35-4

中文名称 托普雄酮
CAS 60607-35-4
分子式 C22H34O2
分子量 330.5
MOL 文件 60607-35-4.mol
60607-35-4 结构式 60607-35-4 结构式

基本信息

中文别名
托普雄酮
英文别名
topterone
Win-17665
17β-Hydroxy-17-propylandrost-4-en-3-one
Androst-4-en-3-one, 17-hydroxy-17-propyl-, (17β)-

物理化学性质

熔点114.6-116.0 °C(Solv: benzene (71-43-2); hexane (110-54-3))
沸点459.8±45.0 °C(Predicted)
密度1.08±0.1 g/cm3(Predicted)
酸度系数(pKa)15.13±0.60(Predicted)

常见问题列表

生物活性
Topterone 是一种局部抗雄激素。
靶点

Androgen

体内研究

Topterone, is administered parenterally or topically to rats, rabbits or hamsters to determine its endocrine profile. Systemic administration demonstrates that Topterone is both antiandrogenic and progestational. Topical application fails to elicit a systemic antiandrogenic response at 1 g/kg/day and only a minimal progestational response is seen at 32 mg/kg/day. No other endocrine activities are detected. Topterone inhibits stimulation of flank organ development of castrated immature male hamsters by both testosterone and dihydrotestosterone, whereas Progesterone inhibits the stimulation by only testosterone. Topical application of Topterone, has been shown to cause a regression in the development of the flank organ.

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