61177-44-4
61177-44-4 结构式
基本信息
中文别名
克拉维酸锂 EP标准品 英文别名
purity 96-98%Clavulanate LithiuM
Lithium clavulanoate
Lithium clavulanate CRS
Lithium (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
(2R,3Z,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid lithium salt
(2R,3Z,5β)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid lithium salt
LithiuM (2R-(2alpha,3(Z),5alpha))-3-(2-hydroxyethylidene)-4-oxa-7-oxo-1-azabicyclo(3.2.0)heptane-2-carboxylate
lithium [2R-(2alpha,3(Z),5alpha)]-3-(2-hydroxyethylidene)-4-oxa-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
物理化学性质
熔点>234°C (dec.)
储存条件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度Methanol (Slightly, Heated, Sonicated), Water (Slightly)
形态neat
颜色Light Beige to Brown
稳定性Hygroscopic
常见问题列表
生物活性
Clavulanate lithium 是一种高效的 β-lactamase 抑制剂,可作为抗生素。靶点
β-lactamase
体外研究
Clavulanate lithium has weak antibacterial activity against most organisms when administered alone, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase.
Clavulanate lithium (0.25, 0.5 mg/L) causes a relatively slow inhibition of growth, and a higher concentration (1 mg/L) is only marginally more effective than 0.5 mg/L.
Cell Viability Assay
Cell Line: | L. pneumophila NCTC 1119 |
Concentration: | 0.25 mg/L, 0.5 mg/L, 1 mg/L |
Incubation Time: | 0-35 hours |
Result: | Caused a relatively slow inhibition of growth. |