622795-76-0
622795-76-0 结构式
基本信息
中文别名
化合物 T9126 英文别名
PIP-199PIP-199 ethyl 4-((1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl)piperazine-1-carboxylate
物理化学性质
沸点655.1±65.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
储存条件-20°C储存
酸度系数(pKa)13.19±0.58(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
PIP-199 是一种 RecQ 介导的基因组不稳定蛋白 RMI 核心复合物/MM2 相互作用 (RMI core complex/MM2 interaction) 的选择性抑制剂，其 IC50 值为 36 μM。PIP-199 可用于耐受肿瘤对 DNA 交联化疗药物的增敏研究。靶点
IC50: 36 μM (RMI core complex/MM2 interaction)
体外研究
MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM).
Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies.
Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents.