623-58-5
中文名称
3-氧代丁酸钠盐
英文名称
ACETYLACETICACID,SODIUMSALT
CAS
623-58-5
分子式
C4H6O3
MOL 文件
623-58-5.mol
更新日期
2024/11/01 09:34:41
623-58-5 结构式
基本信息
中文别名
乙酰乙酸钠3-氧代丁酸钠盐
英文别名
Arbidol Impurity 45Sodium 3-oxobutanoate
sodium 2-acetoxyacetate
ACETYLACETICACID,SODIUMSALT
Acetoacetic acid sodium salt
3-Oxobutyric acid sodium salt
3-Oxobutanoic acid sodium salt
Sodium Acetoacetate DISCONTINUED. Please see L469065.
所属类别
有机原料：羧酸类化合物及衍生物物理化学性质
沸点52 °C(Press: 5 Torr)
储存条件Store at -20°C,unstable in solution, ready to use.
形态Solid
颜色White to off-white
水溶解性Water: 50 mg/mL (403.00 mM)
常见问题列表
生物活性
Acetoacetic acid sodium salt 是一种非酯化脂肪酸代谢物，参与人类糖尿病的发展。Acetoacetic acid sodium salt 诱导氧化应激，抑制牛肝细胞中极低密度脂蛋白的组装。体外研究
Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes.
Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH) group, decreases mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in all groups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition, Acetoacetic acid down-regulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG) accumulation is increased in these bovine hepatocytes.