627034-85-9
627034-85-9 结构式
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-112461A | NF449 NF449 octasodium | 627034-85-9 | 1mg | 1020元 |
| 2025/02/08 | HY-112461A | NF449 octasodium | 627034-85-9 | 5 mg | 2150元 |
| 2025/02/08 | HY-112461A | NF449 octasodium | 627034-85-9 | 10 mg | 3400元 |
常见问题列表
NF449 suppressed the rate of GTP[γS] binding to rG sα-s while barely affecting binding to rG iα-1 (IC 50 =140 nM), inhibits stimulation of adenylyl cyclase activity in S49 cyc− membranes (deficient in endogenous Gsα) by exogenously added Gsα-s, and blocks the coupling of β-adrenergic receptors to G s (EC 50 =7.9 μM).
At a dose of 10 mg/kg, NF449 inhibits the ex vivo aggregation triggered by 5 g/ml collagen in WT mouse platelets without affecting that induced by 5 μM ADP. At a higher dose (50 mg/kg), NF449 inhibits ex vivo platelet aggregation in response to not only 10 g/ml collagen but also 5 M ADP, indicating nonselective inhibition of the P2Y1 and/or P2Y12 receptor.