65089-17-0
65089-17-0 结构式
基本信息
中文别名
匹立昔尔化合物 T13821
英文别名
Pirinixil2-[[4-Chloro-6-(2,3-dimethylphenylamino)-2-pyrimidinyl]thio]-N-(2-hydroxyethyl)acetamide
2-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]thio]-N-(2-hydroxyethyl)acetamide
Acetamide, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-N-(2-hydroxyethyl)-
物理化学性质
熔点145°C
沸点609.6±55.0 °C(Predicted)
密度1.2894 (rough estimate)
折射率1.6100 (estimate)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)13.27±0.46(Predicted)
常见问题列表
生物活性
Pirinixil 是一种低毒性降血脂药。体内研究
Pirinixil is a hypolipidemic agent of low toxicity. Total cholesterol is reduced by Pirinixi in the spleen, kidney and heart of rats. Pirinixil decreases the estimated total body cholesterol approximately 40%. Pirinixil increases plasma cholesterol levels significantly without affecting plasma triglycerides. Liver cholesterol and triglycerides are markedly reduced by Pirinixil, while combined plasma and liver lipid levels decrease approximately 20%. Liver HMG-CoA reductase activity is not affected, but cholesterol 7α-hydroxylase is significantly reduced by Pirinixil.