65528-98-5
中文名称
1-Oleoyl Lysophosphatidic Acid
英文名称
1-Oleoyl Lysophosphatidic Acid
CAS
65528-98-5
分子式
C21H41O7P
分子量
436.52
MOL 文件
65528-98-5.mol
65528-98-5 结构式
基本信息
英文别名
WRGQSWVCFNIUNZ-GDCKJWNLSA-N1-Oleoyl Lysophosphatidic Acid Exclusive
9-Octadecenoic acid (9Z)-, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester
物理化学性质
沸点581.5±60.0 °C(Predicted)
密度1.103±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMF: 2 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 3 mg/ml
酸度系数(pKa)1.82±0.10(Predicted)
形态Liquid
颜色Colorless to light yellow
常见问题列表
生物活性
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) 是一种丰富的溶血磷脂酸种类，由于其对 LPA 受体 (LPA receptors) 的强亲和力，具有很高的生物活性。1-Oleoyl lysophosphatidic acid 在大多数实验室中常用作 LPA 受体激活的试剂。1-Oleoyl lysophosphatidic acid 可增加 SRE 驱动的 β-galactosidase 的活性。体内研究
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) (0.4-2 μg; i.c.v.; 9-week-old male Wistar rats) induces anxiety-like responses in the elevated plus maze (EPM) under novelty conditions.
| Animal Model: | 9-week-old male Wistar rats |
| Dosage: | 0.4-2 μg |
| Administration: | I.c.v. |
| Result: | Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM. |