65836-72-8
中文名称
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
英文名称
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
CAS
65836-72-8
分子式
C11H14ClNO3
分子量
243.69
MOL 文件
65836-72-8.mol
更新日期
2023/09/09 21:38:28
65836-72-8 结构式
基本信息
中文别名
2-氯-N-((34-二甲氧苯基)甲基)乙酰胺
UBA5抑制剂(DKM 2-93)
2-氯-N-(3,4-二甲氧基苄基)乙酰胺
2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺
2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺
乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-
英文别名
DKM 2-93Brn 2857211
CHEMBRDG-BB 9070724
N-(Dimethoxy-3,4 benzyl)-chloroacetamide
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide
Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
物理化学性质
熔点116-118 °C(Solv: carbon tetrachloride (56-23-5))
沸点425.7±45.0 °C(Predicted)
密度1.194±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 150 mg/mL (615.54 mM)
酸度系数(pKa)13.42±0.46(Predicted)
形态Solid
颜色White to light yellow
安全数据
警示词危险
危险性描述H301-H311-H331-H341
防范说明P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
危险品标志Xi
危险等级IRRITANT
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 50mg | 660元 |
| 2024/08/19 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 10mM * 1mLin DMSO | 726元 |
| 2024/08/19 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 100mg | 990元 |
常见问题列表
生物活性
DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。靶点
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
体外研究
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
体内研究
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.