65893-94-9
中文名称
GLABRESCIONE B
英文名称
Glabrescione B
CAS
65893-94-9
分子式
C27H30O6
分子量
450.52
MOL 文件
65893-94-9.mol
65893-94-9 结构式
基本信息
英文别名
GlaBGlabrescione B
Glabrescione B (GlaB)
3-[3,4-bis-(3-methyl-but-2-enyloxy)-phenyl]-5,7-dimethoxy-chromen-4-one
4H-1-Benzopyran-4-one, 3-[3,4-bis[(3-methyl-2-buten-1-yl)oxy]phenyl]-5,7-dimethoxy-
常见问题列表
生物活性
Glabrescione B 是第一个结合 Hedgehog (Hh) 调节剂 Gli1 并通过干扰 Gli1-DNA 相互作用而削弱其活性的化合物。Glabrescione B 抑制 Hedgehog 依赖性肿瘤细胞的生长，抑制肿瘤源性干细胞的自我更新能力和克隆能力。靶点
Gli1-DNA Interaction
体外研究
Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma.
Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels.
Cell Proliferation Assay
| Cell Line: | ASZ001 BCC cells |
| Concentration: | 5 μM |
| Incubation Time: | 24-72 hours |
| Result: | Basal cell carcinoma cell proliferation was impaired. |
Western Blot Analysis
| Cell Line: | ASZ001 BCC cells |
| Concentration: | 1-10 μM |
| Incubation Time: | 24-48 hours |
| Result: | Gli1 mRNA expression levels was decreased. |
体内研究
| Animal Model: | Female NOD/SCID mice (ASZ001 BCC allografts) |
| Dosage: | 100 μmol/kg |
| Administration: | I.p.; every second day for 18 days |
| Result: | A significant reduction of tumor growth as well as Gli1 mRNA levels was observed. |