664334-36-5
中文名称
BKT140
英文名称
BL-8040
CAS
664334-36-5
分子式
C97H144FN33O19S2
分子量
2159.52
MOL 文件
664334-36-5.mol
更新日期
2024/10/12 11:50:32
664334-36-5 结构式
基本信息
中文别名
化合物 T14665 英文别名
BKT140BL-8040
TF14016
BKT140, >99%
Motixafortide
BKT140 (BL-8040)
4F-Benzoyl-TN14003
BKT140CXCR4 antagonist
BKT140 4-fluorobenzoyl
MOTIXAFORTIDE
BL-8040
TF14016
物理化学性质
密度1.52±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度≥216 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic; ≥52.4 mg/mL in H2O
形态结晶固体
颜色White to off-white
BKT140价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | S9665 | BKT140 Motixafortide (BL-8040) | 664334-36-5 | 5mg | 3600.13元 |
| 2024/08/19 | S9665 | BKT140 Motixafortide (BL-8040) | 664334-36-5 | 25mg | 7770元 |
| 2024/08/19 | HY-P0171 | BKT140 Motixafortide | 664334-36-5 | 5mg | 2800元 |
常见问题列表
生物活性
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) 是一种 CXCR4 的拮抗剂，IC50值约为1 nM。BL-8040 通过改变的miR-15a/16-1的表达，下调 ERK、BCL-2、MCL-1 和 cyclin-D1，诱导AML胚的凋亡。靶点
| Target | Value |
|
ERK
() | |
|
Bcl-2
() | |
|
MCL-1
() | |
|
cyclin-D1
() | |
|
CXCR4
(Cell-free assay) | 1 nM |
体外研究
Motixafortide (BKT140) displays selective toxicity toward AmL and MM cells. Treatment with Motixafortide (BKT140) can overcome IL-6 dependent proliferation and survival of ARH77 MM cells. Motixafortide (BKT140) specifically triggers CXCR4-dependent cell death in leukemia and MM cells. Motixafortide (BKT140) stimulates apoptotic cell death in leukemia and MM cells.
体内研究
Subcutaneous injections of Motixafortide (BKT140) significantly reduces, in a dose-dependent manner, the growth of human acute myeloid leukemia and multiple myeloma xenografts. Tumors from animals treated with Motixafortide (BKT140) are smaller in size and weights, had larger necrotic areas and high apoptotic scores.