67-92-5
中文名称
盐酸双环维林
英文名称
DICYCLOMINE HYDROCHLORIDE
CAS
67-92-5
分子式
C19H36ClNO2
分子量
345.95
MOL 文件
67-92-5.mol
更新日期
2024/03/22 17:31:02
67-92-5 结构式
基本信息
中文别名
盐酸双环胺盐酸双环维林
英文别名
atumindyspas
Bentyl)
mamiesan
oxityl-p
bentomine
merbentyl
Magesan P
procyclomin
di-syntramine
所属类别
分析化学：药典标准品和杂质标准品安全数据
警示词警告
危险性描述H302-H315-H319-H335
危险品标志Xn
危险类别码22-36/37/38
安全说明26-36
WGK Germany3
RTECS号DT7350000
海关编码2922199695
毒性LD50 orl-rat: 1290 mg/kg DRUGAY 6,317,82
盐酸双环维林价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-B1339 | 盐酸双环维林 Dicyclomine hydrochloride | 67-92-5 | 100mg | 242元 |
| 2024/01/25 | HY-B1339 | 盐酸双环维林 Dicyclomine hydrochloride | 67-92-5 | 10mM * 1mLin DMSO | 266元 |
| 2024/01/25 | HY-B1339 | 盐酸双环维林 Dicyclomine hydrochloride | 67-92-5 | 500mg | 350元 |
常见问题列表
生物活性
Dicyclomine hydrochloride 是一种有效的口服活性毒蕈碱胆碱能受体 (muscarinic cholinergic receptors) 拮抗剂。Dicyclomine hydrochloride 对 M1 受体亚型 (Ki=5.1 nM) 和 M2 受体亚型 (Ki=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine hydrochloride是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。靶点
Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane)Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane
体内研究
Dicyclomine hydrochloride (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice.Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks.
| Animal Model: | C57Bl/6 mice |
| Dosage: | 2.0, 4.0, and 8.0 mg/kg |
| Administration: | Intraperitoneal injection; daily; 7 days |
| Result: | Produced impairments due to actions of the agent outside of the hippocampus. |