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6729-55-1

中文名称 Γ-D-谷氨酰基甘氨酸
英文名称 H-D-GLU(GLY-OH)-OH
CAS 6729-55-1
分子式 C7H12N2O5
分子量 204.18
MOL 文件 6729-55-1.mol
更新日期 2024/07/14 14:42:52
6729-55-1 结构式 6729-55-1 结构式

基本信息

中文别名
Γ-D-谷氨酰基甘氨酸
Γ-D-GLUTAMYLGLYCINE
英文别名
gDGG
GAMMA DGG
DGG gamma-
-DGG
GAMMA-D-GLU-GLY
D-gamma-Glu-Gly
H-D-GLU(GLY-OH)-OH
γ-D-Glutamylglycine
g-D-Glutamylglycine
H-GAMMA-D-GLU-GLY-OH
所属类别
生物化工:甘氨酸类衍生物

物理化学性质

熔点~191℃
沸点586.6±50.0 °C(Predicted)
密度1.424±0.06 g/cm3(Predicted)
储存条件-15°C
溶解度Water:85.21(Max Conc. mg/mL);417.32(Max Conc. mM)
酸度系数(pKa)2.21±0.10(Predicted)
形态粉末
颜色White to off-white
Γ-D-谷氨酰基甘氨酸价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-100785Γ-D-谷氨酰基甘氨酸
gamma-DGG
6729-55-15mg500元
2024/04/30HY-100785Γ-D-谷氨酰基甘氨酸
gamma-DGG
6729-55-110mM * 1mLin Water550元
2024/04/30HY-100785Γ-D-谷氨酰基甘氨酸
gamma-DGG
6729-55-110mg700元

常见问题列表

生物活性
gamma-DGG 是一种竞争性的 AMPA 受体阻断剂。
靶点

AMPA receptor

体外研究

gamma-DGG (γ-DGG), a competitive AMPA receptor blocker that blocks less at higher glutamate concentration. At 200-400 μM, gamma-DGG in the bath reduces the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses), and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left. gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory post-synaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p. Quantal analysis shows that the reduction in the e.p.s.p. paralleled the decrease in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG.

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