67401-56-3
中文名称
MICROCOCCIN P1
英文名称
13',19'-Didehydro-19'-deoxy-28,44-dihydro-44-hydroxymicrococcin P
CAS
67401-56-3
分子式
C48H49N13O9S6
分子量
1144.37
MOL 文件
67401-56-3.mol
更新日期
2023/03/20 15:41:19
67401-56-3 结构式
基本信息
中文别名
微球菌素P1 英文别名
Brn 1070340Micrococcin P1
MQGFYNRGFWXAKA-QMXXNAFJSA-N
13',19'-Didehydro-19'-deoxy-28,44-dihydro-44-hydroxymicrococcin P
Micrococcin p, 13',19'-didehydro-19'-deoxy-28,44-dihydro-44-hydroxy-
[2,4'-Bithiazole]-4-carboxamide, 2'-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazac...
物理化学性质
密度1.1650 (rough estimate)
折射率1.6700 (estimate)
储存条件-20°C储存
溶解度DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
酸度系数(pKa)10.68±0.46(Predicted)
形态固体
颜色White to yellow
MICROCOCCIN P1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-125728 | MICROCOCCIN P1 Micrococcin P1 | 67401-56-3 | 500μg | 6400元 |
| 2023/03/20 | HY-125728 | MICROCOCCIN P1 Micrococcin P1 | 67401-56-3 | 1mg | 15500元 |
常见问题列表
生物活性
Micrococcin P1 是一种大环肽抗生素，是一种有效的丙型肝炎病毒 (HCV) 抑制剂，EC50 范围为 0.1-0.5 μM。Micrococcin P1 对革兰氏阳性细菌菌株具有体外抗菌活性，对金黄色葡萄球菌 1974149 菌株，粪肠球菌 1674621 菌株和化脓性链球菌 1744264 菌株的 MIC 值分别为 2 μg/ mL，1 μg/ mL 和 1 μg/ mL。Micrococcin P1 还是疟疾寄生虫恶性疟原虫的有效抑制剂。靶点
HCV; Bacterial; Parasite
体外研究
Dose-response assays reveales Micrococcin P1 to be very potent with a minimal inhibitory concentration (MIC) of 32-63 nM. Cytotoxicity assays reveales no significant impairment on cell line growth (<10% inhibition at 30 mM) over a 40 h period for both the hepatic cell line HepG2 and the monocytic cell line THP-1, leading to a selectivity index greater than 500. Also investigats the intracellular activity of Micrococcin P1, it is active against GFP-expressing M. tuberculosis H37Rv growing inside RAW 264.7 macrophages with an IC 80 of about 1 mM with potency comparable with that of isoniazid.