697235-39-5
中文名称
EPISILVESTROL
英文名称
Episilvestrol
CAS
697235-39-5
分子式
C34H38O13
分子量
654.66
MOL 文件
697235-39-5.mol
更新日期
2024/06/20 21:07:18
697235-39-5 结构式
基本信息
中文别名
5MYC-UTR-LUC抑制剂(EPISILVESTROL) 英文别名
Episilvestrol(1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1S)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester
1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S,3R,6R)-6-[(1S)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-
物理化学性质
沸点800.8±65.0 °C(Predicted)
密度1.45±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)11.57±0.70(Predicted)
形态Solid
颜色White to off-white
EPISILVESTROL价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-15359 | EPISILVESTROL Episilvestrol | 697235-39-5 | 1mg | 9900元 |
| 2023/10/26 | HY-15359 | EPISILVESTROL Episilvestrol | 697235-39-5 | 10 mM * 1 mLin DMSO | 71292元 |
常见问题列表
生物活性
Episilvestrol 是 silvestrol 的衍生物，从 Aglaia silvestris 中分到，能够抑制 eIF4A 靶作用的转录过程。靶点
eIF4A
体外研究
Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is cytotoxic activity against several human cancer cell lines, such as Lu1, LNCaP, MCF-7 and HUVEC cells, with ED 50 s of 3.8, 3.8, 5.5 and 15.3 nM, respectively. The GI 50 s of Episilvestrol against the cell proliferation of NCI-H460 and MCF-7 cels are 17.96 nM and 17.96 nM after first test and 15.6 nM and 18.7 nM after 2 months via SRB assay. Episilvestrol also suppresses HK1 cells and EBV-positive C666.1 NPC cells.