70363-83-6
中文名称
双(1,3-二巴比妥酸)-三次甲基氧烯洛尔
英文名称
DIBAC4(3)
CAS
70363-83-6
分子式
C27H40N4O6
分子量
516.63
MOL 文件
70363-83-6.mol
更新日期
2024/08/13 16:01:29
70363-83-6 结构式
基本信息
中文别名
双(1,3-贰丁基巴比妥酸)三次甲基氧杂菁双(1,3-二丁基巴比妥酸)三次甲基氧杂菁
双(1,3-二巴比妥酸)-三次甲基氧烯洛尔
英文别名
DIBAC4(3)Neurodye DiBAC4(3)
BIS(1,3-DIBARBITURIC ACID)-TRIMETHINE OXANOL
Bis(1,3-dibutylbarbituric acid) trimethine oxono
BIS-(1,3-DIBUTYLBARBITURIC ACID)TRIMETHINE OXONOL
Bis(1,3-dibutylbarbituricacid)trimethineoxonol,sodiumsalt
1,3-Dibutyl-5-[3-(1,3-dibutyl-2,4,6-trioxohexahydropyrimidin-5-yl)allylidene]pyrimidine-2,4,6(1H,3H,5H)-trione
2,4,6(1h,3h,5h)-pyrimidinetrione, 1,3- dibutyl-5-[3-(1,3-dibutylhexahydro-2,4,6-trioxo-5-pyrimidinyl)- 2-propenylidene]-
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dibutyl-5-[3-(1,3-dibutylhexahydro-2,4,6-trioxo-5-pyrimidinyl)-2-propen-1-ylidene]-
1,3-Dibutyl-5-(3-(1,3-dibutyl-1,2,3,4-tetrahydro-6-hydroxy-2,4-dioxo-5-pyrimidinyl)-2-propenylidene)-2,4,6(1H,3H,5H)pyrimidinetrione
所属类别
生物化工：荧光成像物理化学性质
熔点>200℃
沸点614.3±65.0 °C(Predicted)
密度1.201±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度在DMF中可溶
酸度系数(pKa)4.80±0.20(Predicted)
形态粉末
颜色橙色
最大波长(λmax)493 nm
生物领域应用Measuring membrane potential; HCN channel modulators; BK channel activator; treating Alzheimer’s disease; antimicrobial susceptibility test; ion channel screening assays; hERG channel assay
常见问题列表
生物活性
DiBAC4(3) 是一种电压敏感的荧光染料 (λex=490 nm，λem=505 nm)。体外研究
The membrane hyperpolarization induced by 10 μM Evans blue (EB) in HEKBKα is clearly observed with DiBAC4(3), while the change in membrane potential (MP) by addition of 3 mM tetraethylammonium chloride (TEA) appears more slowly than that measured with microelectrode. The time to peak of hyperpolarization is 2.3±0.9 s (n=4) and 35.0±2.6 s (n=12, P<0.01) by the measurements with microelectrodes and DiBAC4(3), respectively.