70833-07-7
70833-07-7 结构式
基本信息
中文别名
普呋罗林 英文别名
prifuroline3-(benzofuran-2-yl)-N,N-dimethyl-3,4-dihydro-2H-pyrrol-5-amine
3-(Benzofuran-2-yl)-3,4-dihydro-N,N-dimethyl-2H-pyrrol-5-amine
2H-Pyrrol-5-amine, 3-(2-benzofuranyl)-3,4-dihydro-N,N-dimethyl-
3-(benzofuran-2-yl)-N,N-dimethyl-3,4-dihydro-2H-pyrrol-5-amine(WXC06062)
物理化学性质
沸点383.8±31.0 °C(Predicted)
密度1.18±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)8.55±0.40(Predicted)
常见问题列表
生物活性
Prifuroline 是一种抗心律失常药物。体内研究
Prifuroline is an antiarrhythmic agent. Prifuroline dose-dependently antagonizes the arrhythmogenic action of aconitine in rats, when administered either intravenously (5, 10 or 20 mg/kg) or intraduodenally (10, 20 or 50 mg/kg). Prifuroline also diminishes ventricular susceptibility to electrical stimulation in open-chest rats. The arrhythmias induced in dogs by coronary artery ligation are markedly antagonized by Prifuroline after doses of 5 and 10 mg/kg i.v. or 30 mg/kg intraduodenally. The duration of its antiarrhythmic activity in this model of arrhythmias in conscious dogs is much longer after intraduodenal than after i.v. administration.