71751-77-4
71751-77-4 结构式
基本信息
中文别名
化合物 T16035 英文别名
MELEAGRINMeleagrine
6-O-Methyloxaline, Meleagrine
[3E,7aR,12aS,(-)]-7a-(1,1-Dimethyl-2-propenyl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazole-4-ylmethylene)-12-methoxy-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2(3H),5-dione
1H,5H-Imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione, 7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-, (3E,7aR,12aS)-
常见问题列表
生物活性
Meleagri 是由青霉属 (Penicillium) 真菌产生的具有抗微生物和抗增殖活性的罗奎福汀 C 衍生生物碱。Meleagrin 是一类 FabI 抑制剂。Meleagri 是一种主要的 c-Met 抑制实体,有助于控制 c-Met 依赖性转移和侵袭性乳腺癌。体外研究
Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox.
Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines.
体内研究
Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model.