71774-13-5
中文名称
化合物 T28615
英文名称
ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
CAS
71774-13-5
分子式
C10H12N5O5PS
分子量
345.27
MOL 文件
71774-13-5.mol
71774-13-5 结构式
基本信息
中文别名
化合物 T28615 英文别名
cAMPS-Sp(S)-Adenosine
Sp cAMPS,SpcAMPS
Rp cAMPS TEA salt
Rp-cAMPS TEA salt
Triethylammoniumsalt
camps,sp-isomer,teasalt
ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
Adenosine, cyclic 3',5'-[hydrogen (S)-phosphorothioate]
Adenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
常见问题列表
生物活性
Sp-cAMPS，一种 cAMP 类似物，是一种依赖 cAMP 的 PKA I 和 PKA II 的有效激活剂。Sp-cAMPS 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS 以 EC50 为 40 μM 来结合 PDE10 GAF 域。靶点
|
PKA I
|
PKA II
|
PDE3A 47.6 μM (Ki) |
PDE10 GAF domain 50 μM (EC 50 ) |
体外研究
Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS.
体内研究
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.