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72122-62-4

中文名称 Β-酪啡肽-7
英文名称 BETA-CASOMORPHIN (BOVINE)
CAS 72122-62-4
分子式 C41H55N7O9
分子量 789.92
MOL 文件 72122-62-4.mol
更新日期 2024/07/07 16:57:51
72122-62-4 结构式 72122-62-4 结构式

基本信息

中文别名
Β-酪啡肽-7
婴儿猝死综合征/酪啡肽Β/-CASOMORPHIN抗体
英文别名
YPFPGPI
β-Casomorphin-7
BETA CASOMORPHIN
BETA-CASOMORPHIN-7
β-Casomorphin 7【ox】
β-Casomorphin-7【ox】
β-Casomorphin, bovine
β-Casomorphin(cattle)
b-Casomorphin (bovine)
BETA-CASOMORPHIN (BOVINE)

物理化学性质

储存条件-15°C
溶解度Soluble in DMSO
形态Solid
颜色White to off-white
Β-酪啡肽-7价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-P0179Β-酪啡肽-7
β-Casomorphin, bovine
72122-62-45mg800元
2024/04/30HY-P0179Β-酪啡肽-7
β-Casomorphin, bovine
72122-62-410mg1400元
2024/04/30HY-P0179Β-酪啡肽-7
β-Casomorphin, bovine
72122-62-425 mg2900元

常见问题列表

生物活性
β-casomorphin, bovine (β-Casomorphin-7 (bovine) ) 是阿片 (opioid) 活性的多肽,与阿片受体结合的 IC50 值为 14 μM。
靶点

IC50: 14 μM (Opioid receptor)

体外研究

β-Casomorphin, bovine (0.1 μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment.
β-Casomorphin, bovine (0.1 μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels.
β-Casomorphin, bovine do not modify the expression of rMuc1, rMuc4, and rMuc5AC.
β-Casomorphin, bovine (0.1 μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human).

体内研究

β-Casomorphin, bovine (7.5×10 −6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats.
β-Casomorphin, bovine (7.5×10 −6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats.
β-Casomorphin, bovine (7.5×10 −6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats.
β-Casomorphin, bovine (7.5×10 −6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells.

Animal Model: Male Sprague-Dawley (SD) rats (200 g±10 g)
Dosage: 7.5×10 −6 mol/day/kg
Administration: Oral gavage; for 30 days
Result: Increased plasma insulin and decreased plasma glucagon of diabetic rats.
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