726695-51-8
726695-51-8 结构式
基本信息
物理化学性质
常见问题列表
|
serotonin 460 nM (IC 50 ) |
Syk 41 nM (IC 50 ) |
PKCε 5.1 μM (IC 50 ) |
PKCβ2 11 μM (IC 50 ) |
ZAP-70 11.2 μM (IC 50 ) |
Btk 15.5 μM (IC 50 ) |
Itk 22.6 μM (IC 50 ) |
Syk Inhibitor II (compound 9a) shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC 50 values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively.
Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID 50 value of 13.2 mg/kg.