72734-63-5

中文名称 D2343

英文名称 D 2343

CAS 72734-63-5

分子式 C20H27NO3

分子量 329.43

MOL 文件 72734-63-5.mol

72734-63-5 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T15042

英文别名

D 2343
2-[[3-(2-Methoxyphenyl)-1,1-dimethylpropyl]amino]-1-(p-hydroxyphenyl)ethanol
Benzenemethanol, 4-hydroxy-α-[[[3-(2-methoxyphenyl)-1,1-dimethylpropyl]amino]methyl]-

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

常见问题列表

生物活性

D2343 是一种 β2 肾上腺素能受体激动剂，也是一种 α1-肾上腺素能受体抑制剂。

靶点

β2-adrenoceptor
α1- adrenoceptor

体外研究

D2343 is a compound with about the same beta 2-adrenoceptor-agonist effect as Terbutaline and exhibiting in addition an alpha 1-receptor inhibitory activity. The beta 2-agonistic and alpha 1-antagonistic drug D2343 inhibits the evoked contractions in a concentration related fashion with 50% effect at 9.6 μM.

体内研究

D2343 has been compared to the beta 2-agonist Terbutaline on oestrogenized uterine preparations from rat and rabbit and in myometrial strips from homo. D2343 has shown an ability to relax the uterine muscles to the same degree as Terbutaline or even more, especially when the two drugs are compared in preparations from rabbit and rat.